Search results for "Collective cell migration"

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Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach

2021

International audience; The specific structure of the extracellular matrix (ECM), and in particular the density and orientation of collagen fibres, plays an important role in the evolution of solid cancers. While many experimental studies discussed the role of ECM in individual and collective cell migration, there are still unanswered questions about the impact of nonlocal cell sensing of other cells on the overall shape of tumour aggregation and its migration type. There are also unanswered questions about the migration and spread of tumour that arises at the boundary between different tissues with different collagen fibre orientations. To address these questions, in this study we develop …

0301 basic medicineStatistics and Probabilitymulti-scale hybrid mathematical modelMaterials sciencecell migration[SDV.CAN]Life Sciences [q-bio]/Cancercontinuous cell-extracellular matrix interactionsQA273-280Articlenumerical simulationsExtracellular matrix03 medical and health sciences0302 clinical medicineCollagen fibres[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB][NLIN]Nonlinear Sciences [physics][MATH]Mathematics [math]T57-57.97Applied mathematics. Quantitative methodsApplied MathematicsCollective cell migrationCell migrationTumour invasionCollagen fibre030104 developmental biologyorientation of extracellular matrix fibresagent based discrete cell-cell interactionsContinuous fieldBiological systemProbabilities. Mathematical statistics030217 neurology & neurosurgeryFrontiers in Applied Mathematics and Statistics

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